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Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

29 Apr 2014

Abstract excerpt

In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers...

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PMID: 24781383
DOI: 10.1038/ncomms4746

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