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Article

Significant impact of protein dispensability on the instantaneous rate of protein evolution.

Molecular biology and evolution - 1 Apr 2005

Zhang Jianzhi, He Xionglei

Abstract excerpt

The neutral theory of molecular evolution predicts that important proteins evolve more slowly than unimportant ones. High-throughput gene-knockout experiments in model organisms have provided information on the dispensability, and therefore importance, of thousands of proteins in a genome. However, previous studies of the correlation between protein dispensability and evolutionary rate were equivocal, and it has...

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PMID: 15689524
DOI: 10.1093/molbev/msi101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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