Article
The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.
Blood - 14 May 2009
Novak Urban, Rinaldi Andrea, Kwee Ivo, Nandula Subhadra V, Rancoita Paola M V, Compagno Mara, Cerri Michaela, Rossi Davide, Murty Vundavalli V, Zucca Emanuele, Gaidano Gianluca, Dalla-Favera Riccardo, Pasqualucci Laura, Bhagat Govind, Bertoni Francesco
Abstract excerpt
Unique and shared cytogenetic abnormalities have been documented for marginal zone lymphomas (MZLs) arising at different sites. Recently, homozygous deletions of the chromosomal band 6q23, involving the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) gene, a negative regulator of NF-kappaB, were described in ocular adnexal MZL, suggesting a role for A20 as a tumor suppressor in this disease. Here, we...
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