Article
Comprehensive genomic profiling of orbital and ocular adnexal lymphomas identifies frequent alterations in MYD88 and chromatin modifiers: new routes to targeted therapies.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2016
Cani Andi K, Soliman Moaaz, Hovelson Daniel H, Liu Chia-Jen, McDaniel Andrew S, Haller Michaela J, Bratley Jarred V, Rahrig Samantha E, Li Qiang, Briceño César A, Tomlins Scott A, Rao Rajesh C
Abstract excerpt
Non-Hodgkin lymphoma of the orbit and ocular adnexa is the most common primary orbital malignancy. Treatments for low- (extra-nodal marginal zone and follicular lymphomas) and high-grade (diffuse large B-cell lymphoma) are associated with local and vision-threatening toxicities. High-grade lymphomas relapse frequently and exhibit poor survival rates. Despite advances in genomic profiling and precision medicine,...
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