Article
Recurrent mutations in genes involved in nuclear factor-κB signalling in nodal marginal zone lymphoma-diagnostic and therapeutic implications.
Histopathology - 1 Jan 2017
van den Brand Michiel, Rijntjes Jos, Hebeda Konnie M, Menting Laura, Bregitha Carolyn V, Stevens Wendy B C, van der Velden Walter J F M, Tops Bastiaan B J, van Krieken J Han J M, Groenen Patricia J T A
Abstract excerpt
AIMS: To investigate the spectrum of mutations in 20 genes involved in B-cell receptor and/or Toll-like receptor signalling resulting in activation of nuclear factor-κB (NF-κB) in 20 nodal marginal zone lymphomas (NMZLs), 20 follicular lymphomas (FLs), and 11 cases of B-cell lymphoma, unclassifiable (BCL-u). METHODS AND RESULTS: Nodal marginal zone lymphomas were diagnosed according to strict criteria, including...
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