Article
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia.
The Journal of experimental medicine - 3 Dec 2001
Rosenwald A, Alizadeh A A, Widhopf G, Simon R, Davis R E, Yu X, Yang L, Pickeral O K, Rassenti L Z, Powell J, Botstein D, Byrd J C, Grever M R, Cheson B D, Chiorazzi N, Wilson W H, Kipps T J, Brown P O, Staudt L M
Abstract excerpt
The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a malignancy of mature B cells with a characteristic clinical presentation but a variable clinical course. The rearranged immunoglobulin (Ig) genes of CLL cells may be either germ-line in sequence or somatically mutated. Lack of Ig mutations defined a distinctly worse prognostic group of CLL patients raising the possibility that CLL...
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