Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors.

doi:10.3324/haematol.2016.141812

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors.

Haematologica - 1 Aug 2016

Sutton Lesley-Ann, Young Emma, Baliakas Panagiotis, Hadzidimitriou Anastasia, Moysiadis Theodoros, Plevova Karla, Rossi Davide, Kminkova Jana, Stalika Evangelia, Pedersen Lone Bredo, Malcikova Jitka, Agathangelidis Andreas, Davis Zadie, Mansouri Larry, Scarfò Lydia, Boudjoghra Myriam, Navarro Alba, Muggen Alice F, Yan Xiao-Jie, Nguyen-Khac Florence, Larrayoz Marta, Panagiotidis Panagiotis, Chiorazzi Nicholas, Niemann Carsten Utoft, Belessi Chrysoula, Campo Elias, Strefford Jonathan C, Langerak Anton W, Oscier David, Gaidano Gianluca, Pospisilova Sarka, Davi Frederic, Ghia Paolo, Stamatopoulos Kostas, Rosenquist Richard

Abstract excerpt

We report on markedly different frequencies of genetic lesions within subsets of chronic lymphocytic leukemia patients carrying mutated or unmutated stereotyped B-cell receptor immunoglobulins in the largest cohort (n=565) studied for this purpose. By combining data on recurrent gene mutations (BIRC3, MYD88, NOTCH1, SF3B1 and TP53) and cytogenetic aberrations, we reveal a subset-biased acquisition of gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complementarity Determining Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytogenetic Analysis

Share to Gene Rearrangement, B-Lymphocyte

Share to Genes, Immunoglobulin

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Joining Region

Share to Immunoglobulin Variable Region

Share to Receptors, Antigen, B-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 27198719
DOI: 10.3324/haematol.2016.141812
PMCID: PMC4967575

Genes

NOTCH1
MYD88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors.PMID 27198719Read ↗

Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2.Semantic proximity Read ↗

Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemiaSemantic proximity Read ↗

High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors.Semantic proximity Read ↗

Clonal evolution in chronic lymphocytic leukemia: impact of subclonality on disease progression.Semantic proximity Read ↗

Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical OutcomesSemantic proximity Read ↗

Stereotyped subset #1 chronic lymphocytic leukemia: a direct link between B‐cell receptor structure, function, and patients' prognosisSemantic proximity Read ↗

Stereotyped B-cell receptors in chronic lymphocytic leukemia.Semantic proximity Read ↗

Relevance of Stereotyped B-Cell Receptors in the Context of the Molecular, Cytogenetic and Clinical Features of Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Distinctive Signaling Profiles With Distinct Biological and Clinical Implications in Aggressive CLL Subsets With Stereotyped B-Cell Receptor ImmunoglobulinSemantic proximity Read ↗

Recurrent mutations refine prognosis in chronic lymphocytic leukemia.Semantic proximity Read ↗

Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapiesSemantic proximity Read ↗

The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.