Article
Epidermal growth factor receptor mutations in adenocarcinoma in situ and minimally invasive adenocarcinoma detected using mutation-specific monoclonal antibodies.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2016
Nakamura Haruhiko, Koizumi Hirotaka, Kimura Hiroyuki, Marushima Hideki, Saji Hisashi, Takagi Masayuki
Abstract excerpt
OBJECTIVES: Epidermal growth factor receptor (EGFR) mutation rates in adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) were studied using both DNA analysis and mutation-specific immunohistochemistry. MATERIALS AND METHODS: The peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp method was used to detect mutations in exons 18, 19, 20, and 21 of the EGFR gene in DNA...
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