Article
Immunohistochemical detection of mutated epidermal growth factor receptors in pulmonary adenocarcinoma.
Anticancer research - 1 Dec 2010
Nakamura Haruhiko, Mochizuki Atsushi, Shinmyo Takuo, Ando Koji, Kurimoto Noriaki, Yokote Kumio, Takagi Masayuki
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) mutational analysis has become essential in determining a therapeutic strategy for lung cancer. This study validated the reliability of recently generated rabbit monoclonal antibodies that recognise specific mutations of the EGFR protein. PATIENTS AND METHODS: Pulmonary adenocarcinoma tissue from 20 previously genotyped specimens was prepared for...
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