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Article

Tankyrase inhibition sensitizes cells to CDK4 blockade.

PloS one - 1 Jan 2019

Foronda Miguel, Tarumoto Yusuke, Schatoff Emma M, Leach Benjamin I, Diaz Bianca J, Zimmerman Jill, Goswami Sukanya, Shusterman Michael, Vakoc Christopher R, Dow Lukas E

Abstract excerpt

Tankyrase (TNKS) 1/2 are positive regulators of WNT signaling by controlling the activity of the ß-catenin destruction complex. TNKS inhibitors provide an opportunity to suppress hyperactive WNT signaling in tumors, however, they have shown limited anti-proliferative activity as a monotherapy in human cancer cell lines. Here we perform a kinome-focused CRISPR screen to identify potential effective drug...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 31891587
DOI: 10.1371/journal.pone.0226645
PMCID: PMC6938305

Genes

TNKS
CDK4
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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