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Article

Association of ALDH1A1-NEK-2 axis in cisplatin resistance in ovarian cancer cells

1 Nov 2020

Abstract excerpt

Development of acquired resistance to cisplatin (CDDP) is a major obstacle in the treatment of ovarian cancer patients. According to the cancer stem cell (CSC) hypothesis, the recurrence and chemoresistance are presumed to be linked to cancer stem/progenitor cells. Here, we investigated the CSC-like phenotypes and mechanism of chemoresistance in CDDP resistant ovarian cancer cells. A well-established CDDP...

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PMID: 33241139
DOI: 10.1016/j.heliyon.2020.e05442

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