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Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B

25 Aug 2016

Abstract excerpt

Botulinum neurotoxins (BoNTs) are counted among the most toxic substances known and are responsible for human botulism, a life-threatening disease characterized by flaccid muscle paralysis that occurs naturally by food poisoning or colonization of the gastrointestinal tract by BoNT-producing clostridia. To date, 7 serologically distinct serotypes of BoNT (serotype A-G) are known. Due to the high toxicity of BoNTs...

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PMID: 27560688
DOI: 10.1371/journal.pone.0161446

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