Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New genetic associations in thiopurine-related bone marrow toxicity among inflammatory bowel disease patients.

Pharmacogenomics - 1 Apr 2013

Zabala William, Cruz Raquel, Barreiro-de Acosta Manuel, Chaparro María, Panes Julián, Echarri Ana, Esteve Maria, Carpio Daniel, Andreu Montserrat, García-Planella Esther, Domenech Eugeni, Carracedo Angel, Gisbert Javier P, Barros Francisco

Abstract excerpt

BACKGROUND: The toxicity related to thiopurine drug therapy for inflammatory bowel disease (IBD) varies widely among patients. Almost 15-30% of patients with IBD develop side effects during treatment, often bone marrow suppression. Several factors have been implicated in determining this toxicity, mainly individual genetic variation related to formation of active thiopurine metabolites. The aim was to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Diseases
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokine Receptor gp130

Share to Genome-Wide Association Study

Share to Inflammatory Bowel Diseases

Share to Methyltransferases

Share to Purines

Share to Sulfhydryl Compounds

Source

Identifiers

PMID: 23570467
DOI: 10.2217/pgs.13.38

Genes

FSTL5
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New genetic associations in thiopurine-related bone marrow toxicity among inflammatory bowel disease patients.PMID 23570467Read ↗

Pharmacogenetic Risk Factors for Thiopurine-Induced Leukopenia in Patients with Inflammatory Bowel Disease.Semantic proximity Read ↗

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel DiseaseSemantic proximity Read ↗

Update on thiopurine pharmacogenetics in inflammatory bowel disease.Semantic proximity Read ↗

Pharmacogenetics of Inflammatory Bowel DiseaseSemantic proximity Read ↗

An intronic FTO variant rs16952570 confers protection against thiopurine-induced myelotoxicities in multiethnic Asian IBD patients.Semantic proximity Read ↗

Pharmacogenetics of Thiopurines in Inflammatory Bowel DiseaseSemantic proximity Read ↗

NUDT15,FTO, andRUNX1genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseasesSemantic proximity Read ↗

Prospective study of the effects of concomitant medications on thiopurine metabolism in inflammatory bowel disease.Semantic proximity Read ↗

Revisiting the Role of Thiopurines in Inflammatory Bowel Disease Through Pharmacogenomics and Use of Novel Methods for Therapeutic Drug MonitoringSemantic proximity Read ↗

Pharmacogenetics of treatments for inflammatory bowel diseaseSemantic proximity Read ↗

Risk factors for thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype.Semantic proximity Read ↗

Pharmacogenetics of inflammatory bowel disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.