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Article

An efficient system for selectively altering genetic information within mRNAs.

Nucleic acids research - 1 Dec 2016

Montiel-González Maria Fernanda, Vallecillo-Viejo Isabel C, Rosenthal Joshua J C

Abstract excerpt

Site-directed RNA editing (SDRE) is a strategy to precisely alter genetic information within mRNAs. By linking the catalytic domain of the RNA editing enzyme ADAR to an antisense guide RNA, specific adenosines can be converted to inosines, biological mimics for guanosine. Previously, we showed that a genetically encoded iteration of SDRE could target adenosines expressed in human cells, but not efficiently. Here...

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Source

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Identifiers

PMID: 27557710
DOI: 10.1093/nar/gkw738
PMCID: PMC5137428

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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