Article
Pivotal Role of TNF-α in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Jan 2018
Kakino Satomi, Ohki Tsuyoshi, Nakayama Hitomi, Yuan Xiahong, Otabe Shuichi, Hashinaga Toshihiko, Wada Nobuhiko, Kurita Yayoi, Tanaka Kayo, Hara Kento, Soejima Eri, Tajiri Yuji, Yamada Kentaro
Abstract excerpt
Previously, we have shown that the adipocyte-specific nuclear form of sterol regulatory element-binding protein-1c (nSREBP-1c) transgenic mice spontaneously developed hepatic lesions that are similar to those of human nonalcoholic steatohepatitis (NASH) with a concomitant elevation of plasma TNF-α. In this study, we analyzed the role of TNF-α in the progression of nonalcoholic fatty liver disease (NAFLD). We...
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