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Article

The central role of Fas‐ligand cell signaling in inflammatory lung diseases

1 Jul 2004

Abstract excerpt

Following inflammation and injury in the lung, loss of epithelial cell precursors could determine the balance between tissue regeneration and fibrosis. This review discusses evidence that proapoptotic Fas-Fas ligand (FasL) signaling plays a central role in pulmonary inflammation, injury and fibrosis. FasL signaling induces inflammatory apoptosis in epithelial cells and alveolar macrophages, with concomitant IL-1...

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Share to Cell death mechanisms and regulation
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Identifiers

PMID: 15491504
DOI: 10.1111/j.1582-4934.2004.tb00318.x

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