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Article

Association of Hyperreflective Foci Present in Early Forms of Age-Related Macular Degeneration With Known Age-Related Macular Degeneration Risk Polymorphisms.

Investigative ophthalmology & visual science - 1 Aug 2016

Altay Lebriz, Scholz Paula, Schick Tina, Felsch Moritz, Hoyng Carel B, den Hollander Anneke I, Langmann Thomas, Fauser Sascha

Abstract excerpt

PURPOSE: We evaluated the association of hyperreflective foci (HF) observed in early and intermediate age-related macular degeneration (AMD) with known AMD risk alleles. METHODS: In this pilot case-control study, HF were defined as lesions with reflectivity equal or higher than the retinal pigment epithelium band in spectral domain optical coherence tomography (SDOCT). Hyperreflective foci in the outer nuclear...

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Source

Identifiers

PMID: 27552409
DOI: 10.1167/iovs.15-18855

Genes

ARMS2
CFH
TOMM40
VEGFA
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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