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Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering

23 Aug 2016

Abstract excerpt

Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions. Rational genetic engineering for the production of natural product derivatives is desirable for the purpose of incorporating new functionalities into pre-existing molecules, or for optimization of known...

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PMID: 27551732
DOI: 10.1371/journal.pone.0161199

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