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Article

Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer

22 Feb 2010

Abstract excerpt

BACKGROUND: Aurora B kinase is an important mitotic kinase involved in chromosome segregation and cytokinesis. It is overexpressed in many cancers and thus may be an important molecular target for chemotherapy. AZD1152 is the prodrug for AZD1152-HQPA, which is a selective inhibitor of Aurora B kinase activity. Preclinical antineoplastic activity of AZD1152 against acute myelogenous leukemia, multiple myeloma and...

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PMID: 20175926
DOI: 10.1186/1476-4598-9-42

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