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Article

Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.

Human molecular genetics - 15 Nov 2012

Møllersen Linda, Rowe Alexander D, Illuzzi Jennifer L, Hildrestrand Gunn A, Gerhold Katharina J, Tveterås Linda, Bjølgerud Anja, Wilson David M, Bjørås Magnar, Klungland Arne

Abstract excerpt

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by trinucleotide repeat (TNR) expansions. We show here that somatic TNR expansions are significantly reduced in several organs of R6/1 mice lacking exon 2 of Nei-like 1 (Neil1) (R6/1/Neil1(-/-)), when compared with R6/1/...

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Source

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Identifiers

PMID: 22914735
DOI: 10.1093/hmg/dds337
PMCID: PMC3607484

Genes

TNR
NEIL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22914735-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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