Article
DNA adenine methylation is involved in persister formation in E. coli.
Microbiological research - 1 May 2021
Xu Yuanyuan, Liu Shuang, Zhang Ying, Zhang Wenhong
Abstract excerpt
Uropathogenic Escherichia coli (UPEC) is a major cause of urinary tract infections (UTI). UPEC persister bacteria play crucial roles in clinical treatment failure and relapse. Although DNA methylation is known to regulate gene expression, its role in persister formation has not been investigated. Here, we show that Δdam (adenine methylase) mutant from UPEC strain UTI89 had significant defect in persister...
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