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Identification of a novel gene argJ involved in arginine biosynthesis critical for persister formation in Staphylococcus aureus.

Discovery medicine - 1 Jan 2020

Yee Rebecca, Cui Peng, Shi Wanliang, Feng Jie, Wang Jiou, Zhang Ying

Abstract excerpt

Staphylococcus aureus can cause both acute and recurrent persistent infections such as peritonitis, endocarditis, abscesses, osteomyelitis, and chronic wound infections. Effective therapies to treat persistent disease are paramount. However, the mechanisms of S. aureus persistence are poorly understood. In this study, we performed a comprehensive and unbiased high-throughput mutant screen against a...

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PMID: 32598864

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