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Article

Inflammation and p53: A Tale of Two Stresses

1 Apr 2011

Abstract excerpt

Numerous observations indicate a strong link between chronic inflammation and cancer. This link is supported by substantial experimental evidence indicating mutual negative regulation of NF-κB, the major regulator of inflammation, and p53, the major tumor suppressor. This antagonistic relationship reflects the opposite principles of the physiological responses driven by these transcription factors, which act as...

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PMID: 21779518
DOI: 10.1177/1947601911409747

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