Article
Widespread parainflammation in human cancer.
Genome biology - 8 Jul 2016
Aran Dvir, Lasry Audrey, Zinger Adar, Biton Moshe, Pikarsky Eli, Hellman Asaf, Butte Atul J, Ben-Neriah Yinon
Abstract excerpt
BACKGROUND: Chronic inflammation has been recognized as one of the hallmarks of cancer. We recently showed that parainflammation, a unique variant of inflammation between homeostasis and chronic inflammation, strongly promotes mouse gut tumorigenesis upon p53 loss. Here we explore the prevalence of parainflammation in human cancer and determine its relationship to certain molecular and clinical parameters...
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