Effect of NF-κB Signaling on Apoptosis in Chronic Inflammation-Associated Carcinogenesis

Abstract excerpt

The causal relationship between inflammation and cancer has been documented for sometime, but its molecular nature remains ill defined. Increasing evidence suggested that inflammatory microenvironment in and around tumors is an indispensable participant in the neoplastic process. High level of free radicals produced during inflammation significantly induces DNA damage while evading apoptosis, a hallmark of...

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