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Article

A single dividing cell population with imbalanced fate drives oesophageal tumour growth.

Nature cell biology - 1 Sept 2016

Frede Julia, Greulich Philip, Nagy Tibor, Simons Benjamin D, Jones Philip H

Abstract excerpt

Understanding the cellular mechanisms of tumour growth is key for designing rational anticancer treatment. Here we used genetic lineage tracing to quantify cell behaviour during neoplastic transformation in a model of oesophageal carcinogenesis. We found that cell behaviour was convergent across premalignant tumours, which contained a single proliferating cell population. The rate of cell division was not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27548914
DOI: 10.1038/ncb3400
PMCID: PMC5870829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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