Article
To cycle or not to cycle: a critical decision in cancer.
Nature reviews. Cancer - 1 Dec 2001
Malumbres M, Barbacid M
Abstract excerpt
Tumour cells undergo uncontrolled proliferation, yet tumours most often originate from adult tissues, in which most cells are quiescent. So, the proliferative advantage of tumour cells arises from their ability to bypass quiescence. This can be due to increased mitogenic signalling and/or alterations that lower the threshold required for cell-cycle commitment. Understanding the molecular mechanisms that underlie...
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