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Article

Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells.

PLoS genetics - 1 Jan 2015

Boer Elena F, Howell Elizabeth D, Schilling Thomas F, Jette Cicely A, Stewart Rodney A

Abstract excerpt

Directional migration of neural crest (NC) cells is essential for patterning the vertebrate embryo, including the craniofacial skeleton. Extensive filopodial protrusions in NC cells are thought to sense chemo-attractive/repulsive signals that provide directionality. To test this hypothesis, we generated null mutations in zebrafish fascin1a (fscn1a), which encodes an actin-bundling protein required for filopodia...

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Identifiers

PMID: 25607881
DOI: 10.1371/journal.pgen.1004946
PMCID: PMC4301650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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