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Article

Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product.

Journal of the American Chemical Society - 14 Sept 2016

Volbeda Anne, Darnault Claudine, Renoux Oriane, Reichmann Debora, Amara Patricia, Ollagnier de Choudens Sandrine, Fontecilla-Camps Juan C

Abstract excerpt

The enzyme NadA catalyzes the synthesis of quinolinic acid (QA), the precursor of the universal nicotinamide adenine dinucleotide (NAD) cofactor. Here, we report the crystal structures of complexes between the Thermotoga maritima (Tm) NadA K219R/Y107F variant and (i) the first intermediate (W) resulting from the condensation of dihydroxyacetone phosphate (DHAP) with iminoaspartate and (ii) the DHAP analogue and...

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PMID: 27545412
DOI: 10.1021/jacs.6b05884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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