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Article

Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation.

Biochemistry - 11 Feb 2014

Light Samuel H, Antanasijevic Aleksandar, Krishna Sankar N, Caffrey Michael, Anderson Wayne F, Lavie Arnon

Abstract excerpt

A component of the shikimate biosynthetic pathway, dehydroquinate dehydratase (DHQD) catalyzes the dehydration of 3-dehydroquniate (DHQ) to 3-dehydroshikimate. In the type I DHQD reaction mechanism a lysine forms a Schiff base intermediate with DHQ. The Schiff base acts as an electron sink to facilitate the catalytic dehydration. To address the mechanism of Schiff base formation, we determined structures of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24437575
DOI: 10.1021/bi4015506
PMCID: PMC3985847

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