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Article

Dynamics of PBMC gene expression in hepatitis C virus genotype 1-infected patients during combined peginterferon/ribavirin therapy.

Oncotarget - 20 Sept 2016

Lu Ming-Ying, Huang Ching-I, Hsieh Ming-Yen, Hsieh Tusty-Juan, Hsi Edward, Tsai Pei-Chien, Tsai Yi-Shan, Lin Ching-Chih, Hsieh Meng-Hsuan, Liang Po-Cheng, Lin Yi-Hung, Hou Nai-Jen, Yeh Ming-Lun, Huang Chung-Feng, Lin Zu-Yau, Chen Shinn-Cherng, Huang Jee-Fu, Chuang Wan-Long, Dai Chia-Yen, Yu Ming-Lung

Abstract excerpt

Hepatitis C virus (HCV) can replicate in peripheral blood mononuclear cells (PBMCs), which can produce interferon to defend against virus infection. We hypothesized that dynamic gene expression in PBMCs might impact the treatment efficacy of peginterferon/ribavirin in HCV patients. PBMCs were collected at baseline, 1st week and 4th week of treatment from 27 chronic HCV-1 patients with 48-week...

Read the complete abstract on PubMed

Topics

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Share to Antiviral Agents
Share to Drug Therapy, Combination

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Interferon-alpha

Share to Leukocytes, Mononuclear

Share to Polyethylene Glycols

Share to Ribavirin

Share to Sequence Analysis, RNA

Source

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Identifiers

PMID: 27542257
DOI: 10.18632/oncotarget.11348
PMCID: PMC5308654

Genes

DDX60
HERC5
HERC6
IFI44
IFITM3
RSAD2
SERPING1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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