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Article

Methotrexate therapy of T-cell large granular lymphocytic leukemia impact of STAT3 mutation.

Oncotarget - 20 Sept 2016

Qiu Zhi-Yuan, Fan Lei, Wang Rong, Gale Robert Peter, Liang Hua-Jin, Wang Man, Wang Li, Wu Yu-Jie, Qiao Chun, Chen Yao-Yu, Xu Wei, Qian Jun, Li Jian-Yong

Abstract excerpt

T-cell large granular lymphocytic leukemia (T-LGLL) is a rare haematologic neoplasm. Consequntly, there are no large prospective studies of therapy and no uniform therapy recommendations. We analyzed data from 36 subjects receiving methotrexate alone (N = 27) or with prednisone (N = 9) as initial therapy. 31 subjects responded (86%, 95% confidence interval [CI], 73, 95%) with 8 complete responses and 23 partial...

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Large Granular Lymphocytic

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Source

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Identifiers

PMID: 27542218
DOI: 10.18632/oncotarget.11360
PMCID: PMC5308661

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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