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Article

Genetic variants associated with thermal pain sensitivity in a paediatric population.

Pain - 1 Nov 2016

Matic Maja, van den Bosch Gerbrich E, de Wildt Saskia N, Tibboel Dick, van Schaik Ron H N

Abstract excerpt

Pain sensitivity is an inherited factor that varies strongly between individuals. We investigated whether genetic polymorphisms in the candidate genes COMT, OPRM1, OPRD1, TAOK3, TRPA1, TRPV1, and SCN9A are contributing to experimental pain variability between children. Our study included 136 children and adolescents (8-18 years). Cold and heat pain thresholds were determined with a Thermal Sensory Analyzer. Women...

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Source

Identifiers

PMID: 27541715
DOI: 10.1097/j.pain.0000000000000664

Genes

OPRM1
COMT
OPRD1
TAOK3
TRPA1
TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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