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Article

Discovery of a proteinaceous cellular receptor for a norovirus

18 Aug 2016

Abstract excerpt

Noroviruses (NoVs) are a leading cause of gastroenteritis globally, yet the host factors required for NoV infection are poorly understood. We identified host molecules that are essential for murine NoV (MNoV)-induced cell death, including CD300lf as a proteinaceous receptor. We found that CD300lf is essential for MNoV binding and replication in cell lines and primary cells. Additionally, Cd300lf(-/-) mice are...

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Identifiers

PMID: 27540007
DOI: 10.1126/science.aaf1220

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