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Article

Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus

5 May 2023

Abstract excerpt

Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain. To identify receptors conferring reovirus serotype-dependent neuropathogenesis, we conducted a genome-wide CRISPRa screen and identified paired immunoglobulin-like receptor B...

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PMID: 37147336
DOI: 10.1038/s41467-023-38327-6

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