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Article

Impact of variants of MMP-7(-181A>G) gene in susceptibility to the development of HIV-associated neurocognitive disorder and its severity.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Nov 2016

Singh HariOm, Marathe Shruti D, Nain Sumitra, Nema Vijay, Angadi Mansa, Bapat Shradha S, Ghate Manisha V, Gangakhedkar Raman R

Abstract excerpt

The HIV-1-induced neurological toxicity has been associated with the deficiency of matrix metalloproteinases. Tat protein of HIV up regulates MMP-7 release and activation, leading to neurotoxicity. The SNP -181A>G of MMP-7 is known to have functional effects on its promoter activity. Therefore, we aimed to evaluate the association of variants of MMP-7 -181A>G gene in HIV-associated neurocognitive disorder (HAND)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27538541
DOI: 10.1111/apm.12594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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