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Matrix metalloproteinases, their production by monocytes and macrophages and their potential role in HIV-related diseases

7 Sept 2006

Abstract excerpt

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are a subfamily of metzincins. Matrix metalloproteinases are responsible for much of the turnover of extra-cellular matrix components and are key to a wide range of processes including tissue remodeling and release of biological factors. Imbalance between the MMPs and endogenous tissue inhibitors of metalloproteinases (TIMPs) can result in...

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PMID: 16959898
DOI: 10.1189/jlb.0306152

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