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Article

Effect of matrix metalloproteinase-21 (572C/T) polymorphism on HIV-associated neurocognitive disorder.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Apr 2018

Singh HariOm, Samani Dharmesh, Nambiar Nayana, Ghate Manisha V, Gangakhedkar R R

Abstract excerpt

Remodeling of extracellular matrix (ECM) by matrix metalloproteinases (MMPs) is a presumed reason for the development of HIV-associated neurocognitive disorders (HAND). The coding region polymorphism in MMP-21 572C/T gene may have a potential functional effect on ECM remodeling. Hence, we aimed to examine the association of MMP-21 polymorphism with the modulation of HAND severity and its prevalence in...

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PMID: 29575199
DOI: 10.1111/apm.12817

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