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Article

Promoter polymorphism MMP-1 (-1607 2G/1G) and MMP-3 (-1612 5A/6A) in development of HAND and modulation of pathogenesis of HAND.

Journal of biosciences - 1 Sept 2017

Singh Hari Om, Marathe Shruti D, Nain Sumitra, Samani Dharmesh, Nema Vijay, Ghate Manisha V, Gangakhedkar R R

Abstract excerpt

The pathogenesis of HIV-associated neurocognitive disorder (HAND) is modulated by host genetic susceptibility factors such as Matrix metalloproteinases (MMPs). Promoter polymorphism of MMP-1 and MMP-3 may modify the expression of the gene. Hence, we evaluated the association of MMP-1-16072G/1G and MMP-3-1612 5A/6A polymorphisms with development of HAND and the modulation of pathogenesis of HAND. We enrolled a...

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PMID: 29358561
DOI: 10.1007/s12038-017-9694-5

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MMP3

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