Article
Receptor tyrosine kinase kit and gastrointestinal stromal tumours: an overview.
Current medicinal chemistry - 1 Jan 2011
Sartini S, Dario B, Morelli M, Da Settimo F, La Motta C
Abstract excerpt
Kit is a growth factor receptor of the type III tyrosine kinase family, whose gain-of-function mutations have been identified as driving causes of different kinds of tumours. It thus represents a viable drug target, and the development of Kit inhibitors has been shown to be a promising therapeutic concept. This review will focus on structural and signalling properties of both wild-type and mutant Kit, as well as...
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