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Article

Global DNA Methylation Is Associated With Insulin Resistance

31 Dec 2011

Abstract excerpt

Insulin resistance (IR), the hallmark of type 2 diabetes, may be under epigenetic control. This study examines the association between global DNA methylation and IR using 84 monozygotic twin pairs. IR was estimated using homeostasis model assessment (HOMA). Global DNA methylation of Alu repeats in peripheral blood leukocytes was quantified by bisulfite pyrosequencing. The association between global DNA...

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PMID: 22210312
DOI: 10.2337/db11-1048

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