Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses

18 Aug 2016

Abstract excerpt

ABSTRACT RNA viruses present an extraordinary threat to human health, given their sudden and unpredictable appearance, the potential for rapid spread among the human population, and their ability to evolve resistance to antiviral therapies. The recent emergence of chikungunya virus, Zika virus, and Ebola virus highlights the struggles to contain outbreaks. A significant hurdle is the availability of antivirals to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cannabis and Cannabinoid Research
Share to CRISPR and Genetic Engineering
Share to Polyamine Metabolism and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27535047
DOI: 10.1128/jvi.01347-16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA VirusesPMID 27535047Read ↗

Polyamine Depletion Inhibits Bunyavirus Infection via Generation of Noninfectious Interfering VirionsSemantic proximity Read ↗

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness.Semantic proximity Read ↗

Polyamine Analog Diethylnorspermidine Restricts Coxsackievirus B3 and Is Overcome by 2A Protease Mutation In Vitro.Semantic proximity Read ↗

A perspective of polyamine metabolismSemantic proximity Read ↗

Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and ReplicationSemantic proximity Read ↗

Targeting viral genome synthesis as broad-spectrum approach against RNA virus infectionsSemantic proximity Read ↗

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastomaSemantic proximity Read ↗

Spermidine and spermine are the natural substrates of the <i>Acinetobacter baumannii</i> AmvA multidrug efflux pumpSemantic proximity Read ↗

2-Thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA virusesSemantic proximity Read ↗

Substrate and target selectivity of 4′-fluoroadenosine against viral and host polymerasesSemantic proximity Read ↗

Targeting polyamine metabolism for cancer therapy and preventionSemantic proximity Read ↗

Astrovirus Replication Is Inhibited by Nitazoxanide In Vitro and In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.