Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle.

PloS one - 1 Jan 2015

Gonzalez-Recio Oscar, Daetwyler Hans D, MacLeod Iona M, Pryce Jennie E, Bowman Phil J, Hayes Ben J, Goddard Michael E

Abstract excerpt

The proportion of genetic variation in complex traits explained by rare variants is a key question for genomic prediction, and for identifying the basis of "missing heritability"--the proportion of additive genetic variation not captured by common variants on SNP arrays. Sequence variants in transcript and regulatory regions from 429 sequenced animals were used to impute high density SNP genotypes of 3311...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cattle
Share to MAF gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Polymorphism, Single Nucleotide

Share to Regulatory Sequences, Nucleic Acid

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 26642058
DOI: 10.1371/journal.pone.0143945
PMCID: PMC4671594

Genes

MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle.PMID 26642058Read ↗

Contribution of rare and low-frequency whole-genome sequence variants to complex traits variation in dairy cattle.Semantic proximity Read ↗

Variance explained by whole genome sequence variants in coding and regulatory genome annotations for six dairy traits.Semantic proximity Read ↗

Variance component estimates for growth traits in beef cattle using selected variants from imputed low-pass sequence data.Semantic proximity Read ↗

Comparison of gene-based rare variant association mapping methods for quantitative traits in a bovine population with complex familial relationships.Semantic proximity Read ↗

Estimates of missing heritability for complex traits in Brown Swiss cattle.Semantic proximity Read ↗

Multi-breed genomic prediction using Bayes R with sequence data and dropping variants with a small effect.Semantic proximity Read ↗

Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traitsSemantic proximity Read ↗

Contribution of rare coding variants to complex trait heritabilitySemantic proximity Read ↗

Mining massive genomic data of two Swiss Braunvieh cattle populations reveals six novel candidate variants that impair reproductive success.Semantic proximity Read ↗

A method to estimate the contribution of rare coding variants to complex trait heritability.Semantic proximity Read ↗

Bayesian genome-wide analysis of cattle traits using variants with functional and evolutionary significanceSemantic proximity Read ↗

A multi-breed reference panel and additional rare variants maximize imputation accuracy in cattle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.