Article
Identifying rare variants associated with complex traits via sequencing.
Current protocols in human genetics - 1 Jul 2013
Li Bingshan, Liu Dajiang J, Leal Suzanne M
Abstract excerpt
Although genome-wide association studies have been successful in detecting associations with common variants, there is currently an increasing interest in identifying low-frequency and rare variants associated with complex traits. Next-generation sequencing technologies make it feasible to survey the full spectrum of genetic variation in coding regions or the entire genome. The association analysis for rare...
Topics
- Algorithms
- Chromosome Mapping
- Genetic Variation
- Genome-Wide Association Study
- High-Throughput Nucleotide Sequencing
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Multifactorial Inheritance
- Quantitative Trait, Heritable