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Article

Contribution of rare and low-frequency whole-genome sequence variants to complex traits variation in dairy cattle.

Genetics, selection, evolution : GSE - 1 Aug 2017

Zhang Qianqian, Calus Mario P L, Guldbrandtsen Bernt, Lund Mogens Sandø, Sahana Goutam

Abstract excerpt

BACKGROUND: Whole-genome sequencing and imputation methodologies have enabled the study of the effects of genomic variants with low to very low minor allele frequency (MAF) on variation in complex traits. Our objective was to estimate the proportion of variance explained by imputed sequence variants classified according to their MAF compared with the variance explained by the pedigree-based additive genetic...

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Identifiers

PMID: 28764638
DOI: 10.1186/s12711-017-0336-z
PMCID: PMC5539983

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MAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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