Article
Association of frequent genetic variants in platelet activation pathway genes with large-vessel ischemic stroke in Polish population.
Platelets - 1 Jan 2017
Postula Marek, Janicki Piotr K, Milanowski Lukasz, Pordzik Justyna, Eyileten Ceren, Karlinski Michal, Wylezol Pawel, Solarska Marta, Czlonkowka Anna, Kurkowska-Jastrzebka Iwona, Sugino Shigekazu, Imamura Yuka, Mirowska-Guzel Dagmara
Abstract excerpt
Platelets are critically involved in the development of cerebral ischemia. Our study aimed to establish an association between frequent (minor allele frequency (MAF) > 5%) genetic polymorphisms in 84 candidate genetic loci previously linked to platelet reactivity by the use of next-generation sequencing of exons from pooled DNA samples in Polish patients with a history of large-vessel ischemic stroke. Genetic...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Brain Ischemia
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease