Article
Population-Specific Associations of Deleterious Rare Variants in Coding Region of P2RY1-P2RY12 Purinergic Receptor Genes in Large-Vessel Ischemic Stroke Patients.
International journal of molecular sciences - 11 Dec 2017
Janicki Piotr K, Eyileten Ceren, Ruiz-Velasco Victor, Sedeek Khaled Anwar, Pordzik Justyna, Czlonkowska Anna, Kurkowska-Jastrzebska Iwona, Sugino Shigekazu, Imamura-Kawasawa Yuka, Mirowska-Guzel Dagmara, Postula Marek
Abstract excerpt
The contribution of low-frequency and damaging genetic variants associated with platelet function to ischemic stroke (IS) susceptibility remains unknown. We employed a deep re-sequencing approach in Polish patients in order to investigate the contribution of rare variants (minor allele frequency, MAF < 1%) to the IS genetic susceptibility in this population. The genes selected for re-sequencing consisted of 26...
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