Article
Monogenic, Polygenic, and MicroRNA Markers for Ischemic Stroke.
Molecular neurobiology - 1 Feb 2019
Chen Wu, Sinha Bharati, Li Yi, Benowitz Larry, Chen Qinhua, Zhang Zhenghong, Patel Nirav J, Aziz-Sultan Ali M, Chiocca Antonio E, Wang Xin
Abstract excerpt
Ischemic stroke (IS) is a leading disease with high mortality and disability, as well as with limited therapeutic window. Biomarkers for earlier diagnosis of IS have long been pursued. Family and twin studies confirm that genetic variations play an important role in IS pathogenesis. Besides DNA mutations found previously by genetic linkage analysis for monogenic IS (Mendelian inheritance), recent studies using...
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