Article
Differential lower airway dendritic cell patterns may reveal distinct endotypes of RSV bronchiolitis.
Thorax - 1 Jul 2017
Kerrin Aoife, Fitch Paul, Errington Claire, Kerr Dennis, Waxman Liz, Riding Kay, McCormack Jon, Mehendele Felicity, McSorley Henry, MacKenzie Karen, Wronski Sabine, Braun Armin, Levin Richard, Theilen Ulf, Schwarze Jürgen
Abstract excerpt
RATIONALE: The pathogenesis of respiratory syncytial virus (RSV) bronchiolitis in infants remains poorly understood. Mouse models implicate pulmonary T cells in the development of RSV disease. T cell responses are initiated by dendritic cells (DCs), which accumulate in lungs of RSV-infected mice. In infants with RSV bronchiolitis, previous reports have shown that DCs are mobilised to the nasal mucosa, but data on...
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