Article
TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.
The Journal of clinical investigation - 1 Feb 2015
Caballero Mauricio T, Serra M Elina, Acosta Patricio L, Marzec Jacqui, Gibbons Luz, Salim Maximiliano, Rodriguez Andrea, Reynaldi Andrea, Garcia Alejandro, Bado Daniela, Buchholz Ursula J, Hijano Diego R, Coviello Silvina, Newcomb Dawn, Bellabarba Miguel, Ferolla Fausto M, Libster Romina, Berenstein Ada, Siniawaski Susana, Blumetti Valeria, Echavarria Marcela, Pinto Leonardo, Lawrence Andrea, Ossorio M Fabiana, Grosman Arnoldo, Mateu Cecilia G, Bayle Carola, Dericco Alejandra, Pellegrini Mariana, Igarza Ignacio, Repetto Horacio A, Grimaldi Luciano Alva, Gudapati Prathyusha, Polack Norberto R, Althabe Fernando, Shi Min, Ferrero Fernando, Bergel Eduardo, Stein Renato T, Peebles R Stokes, Boothby Mark, Kleeberger Steven R, Polack Fernando P
Abstract excerpt
While 30%-70% of RSV-infected infants develop bronchiolitis, 2% require hospitalization. It is not clear why disease severity differs among healthy, full-term infants; however, virus titers, inflammation, and Th2 bias are proposed explanations. While TLR4 is associated with these disease phenotypes, the role of this receptor in respiratory syncytial virus (RSV) pathogenesis is controversial. Here, we evaluated...
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